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Epigenetic Changes in Malignant Uveal Melanoma and Possibilities of Their Therapeutic Targeting Journal > /en/journal/2020/2/1
Uveal melanoma (UM) is a deadly cancer that leads to metastatic disease in more than 50 % of the patients. Despite the improvement in the treatment of primary disease, there is still no effective therapy to prevent the development of metastases. Therefore, the disease requires intensive research to identify new treatment strategies. In preclinical UM models, epigenetic drugs have been shown to inc...
The Braf Mutation and the Possibilities of Uveal Melanoma Metastasing Prognostic Markers’ Identification Journal > /en/journal/2016/4/6
Aim: The aim is to assess the BRAF gene mutations in patients with posterior uveal melanoma. Material and methods: Retrospective analysis of the group of patients with malignant melanoma of the uvea, who were indicated to enucleation between 1.1 2015 to 1.3.2016. We analyzed stage of uveal melanoma, volume, cell type and BRAF gene mutations. Results: In clinical study of 20 patients after enucleat...