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<article article-type="research-article" dtd-version="1.3" xml:lang="en">
  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>Czech and Slovak Ophthalmology</journal-title>
      </journal-title-group>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">460</article-id>
      <article-categories>
        <subj-group>
          <subject>Original article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Foveal Hypoplasia Detection by Optical Coherence Tomography</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Bušányová</surname>
            <given-names>Beáta</given-names>
          </name>
          <contrib-id contrib-id-type="orcid">https://orcid.org/0009-0007-8587-9164</contrib-id>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Porubanová</surname>
            <given-names>Miroslava</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Gerinec</surname>
            <given-names>Anton</given-names>
          </name>
        </contrib>
      </contrib-group>
      <pub-date date-type="pub" publication-format="electronic">
        <day>20</day>
        <month>3</month>
        <year>2014</year>
      </pub-date>
      <issue>1</issue>
      <elocation-id>4</elocation-id>
      <abstract>
        <p>Purpose: To evaluate the contribution of optical coherence tomography (OCT) in the diagnosis of foveal hypoplasia in children. Material and methods: Children with foveal hypoplasia (FH) were examinated with device RTVue Fourier – domain (FD) – OCT, software – version 6.8 (Optovue Inc., Fremont, USA). A qualitative examination of the macular area was performed with single horizontal scan (1024 A-scans/frame). Macular thickness was measured and evaluated quantitatively with an automatic fast macular area protocol MM5 (Macular Map 5x5 mm). A control group of children was used for comparison. Results: The quality was assessed with OCT image of the macula and quantitatively evaluated macular thickness and configuration in children with foveal hypoplasia. It was subsequently realized the comparison of macular OCT findings in healthy children. The OCT showed a reduction of foveal depression, continuous extension of the inner retinal layers through the area in which should be normally found fovea. Patients with foveal hypoplasia had thicker central macula and fovea than children in the control group. Conclusion: OCT in our group of patients confirmed the final diagnosis of foveal hypoplasia. FDOCT is a noninvasive and quick method helpful in identifying retinal abnormalities in the diagnosis of foveal hypoplasia in children and may be useful in diagnosing patients with unexplained decrease in vision.</p>
      </abstract>
      <kwd-group>
        <kwd>foveal hypoplasia</kwd>
        <kwd>optical coherence tomography</kwd>
        <kwd>children</kwd>
      </kwd-group>
    </article-meta>
  </front>
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    <ref-list>
      <title>References</title>
      <ref id="R10527">
        <mixed-citation>Cronin, T.H., Hertle, R.W., Ishikawa, H. et al.: Spectral domain optical coherence tomography for detection of foveal morphology in patients with nystagmus. J AAPOS, 2009; 13(6): 563–566.</mixed-citation>
      </ref>
      <ref id="R10528">
        <mixed-citation>Dubis, A.M., Hansen, B.R., Cooper, R.F. et al.: Relationship between the Foveal Avascular Zone and Foveal Pit Morphology. Invest Ophthalmol Vis Sci, 2012; 53: 1628–1636.</mixed-citation>
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      <ref id="R10530">
        <mixed-citation>th degree – same as 3rd degree, but absence of ONL extension. On the basis of the above classification, we also identified the stated changes in our sample of patients, which enabled us to attribute a specific degree of FH. The degree of FH is an important prognostic indicator for CVA, applicable within the scope of diseases associated with FH, with the exception of achromatopsia (7, 13). In the published works, the 1st degree has been linked to the best CVA (up to 0.63), the 2nd, 3rd and 4th degrees are linked to progressively worse CVA (0.4, 0.25, 0.16). We discovered similar findings also in our group, where a higher degree of FH corresponded to progressively lower CVA, although we did not determine a correlation between CVA and foveal thickness. Atypical are symptoms in FH associated with achromatopsia, which is characterised by: • decrease of thickness of retina and ONL, • deeper foveal pit, • disruption of junction IS-OS. In our study the patient with achromatopsia had a typical </mixed-citation>
      </ref>
      <ref id="R10531">
        <mixed-citation>Chong, G., Farsiu, S., Freedman, S.F. et al.: Abnormal Foveal Morphology in Ocular Albinism Imaged With Spectral-Domain Optical Coherence Tomograph. Arch Ophthalmol, 2009; 127(1): 37–44.</mixed-citation>
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      </ref>
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      </ref>
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      </ref>
      <ref id="R10536">
        <mixed-citation>Park, K.A., Oh, S.Y.: Clinical characteristics of high grade foveal hypoplasia. Int Ophthalmol, 2013; 33: 9–14.</mixed-citation>
      </ref>
      <ref id="R10537">
        <mixed-citation>Rossi, S., Testa, F., Gargiulo, A. et al.: The Role of Optical Coherence Tomography in an Atypical Case of Oculocutaneous Albinism: A Case Report. Case Rep Ophthalmol, 2012; 3: 113–117.</mixed-citation>
      </ref>
      <ref id="R10538">
        <mixed-citation>Saffra, N., Agarwal, S., Chiang, J.P.W. et al.: Spectral-Domain Optical Coherence Tomographic Characteristics of Autosomal Recessive Isolated Foveal Hypoplasia. Arch Ophthalmol, 2012; 130(10): 1324–1327.</mixed-citation>
      </ref>
      <ref id="R10539">
        <mixed-citation>Seo, J.H., Yu, Y.S., Kim, J.H. et al.: Correlation of visual acuity with foveal hypoplasia grading by optical coherence tomography in albinism. Ophthalmology, 2007; 114(8): 1547–51.</mixed-citation>
      </ref>
      <ref id="R10540">
        <mixed-citation>Thomas, M.G., Kumar, A., Mohammad, S. et al.: Structural Grading of Foveal Hypoplasia Using Spectral-Domain Optical Coherence Tomography. Ophthalmology, 2011; 118: 1653–1660.</mixed-citation>
      </ref>
      <ref id="R10541">
        <mixed-citation>Yang, H., Yu, T., Sun, C. et al.: Spectral- -domain optical coherence tomography in patients with congenital nystagmus. Int J Ophthalmol, 2011; 4(6): 627–630. absence or abnormal maculofoveal reflex upon ophthalmoscopy, fovea is indistinctly structured and more difficult to differentiate from the other retina. It has less macular lutein visible ophthalmoscopically (1, 4, 5). Upon fluorescence angiography there is variable and incomplete filtration of choroidal fluorescence in the macular area and the avascular zone is very narrow (8). Etiologically the PAX6 gene has been identified, indicating the process of differentiation of the fovea, the mutation of which may cause hypoplasia. Heredity is autosomally dominant or recessive, but sporadic cases have also been described. Determination of a diagnosis of foveal hypoplasia in children is not always easy, since only discrete changes are present on the fundus, and these are frequently more difficult to detect, especially if nystagmus is pre</mixed-citation>
      </ref>
    </ref-list>
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</article>
