<?xml version="1.0" encoding="UTF-8"?>
<article article-type="research-article" dtd-version="1.3" xml:lang="en">
  <front>
    <journal-meta>
      <journal-title-group>
        <journal-title>Czech and Slovak Ophthalmology</journal-title>
      </journal-title-group>
    </journal-meta>
    <article-meta>
      <article-id pub-id-type="publisher-id">42</article-id>
      <article-id pub-id-type="doi">10.31348/2018/1/1-1-2018</article-id>
      <article-categories>
        <subj-group>
          <subject>Original article</subject>
        </subj-group>
      </article-categories>
      <title-group>
        <article-title>Pachychoroid disease of the macula</article-title>
      </title-group>
      <contrib-group>
        <contrib contrib-type="author">
          <name>
            <surname>Stěpanov</surname>
            <given-names>Alexandr</given-names>
          </name>
          <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8462-8756</contrib-id>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Studnička</surname>
            <given-names>Jan</given-names>
          </name>
          <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9911-4379</contrib-id>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Středová</surname>
            <given-names>Miroslava</given-names>
          </name>
        </contrib>
        <contrib contrib-type="author">
          <name>
            <surname>Fialová</surname>
            <given-names>Veronika</given-names>
          </name>
          <contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7976-6759</contrib-id>
        </contrib>
      </contrib-group>
      <pub-date date-type="pub" publication-format="electronic">
        <day>3</day>
        <month>7</month>
        <year>2018</year>
      </pub-date>
      <issue>1</issue>
      <elocation-id>1-1-2018</elocation-id>
      <abstract>
        <p>Stepanov A. – Studnička J. – Středová M. – Fialová V.</p>
      </abstract>
      <kwd-group>
        <kwd>optical koherence tomography</kwd>
        <kwd>OCT</kwd>
        <kwd>pachychoroid</kwd>
        <kwd>EDI scan</kwd>
      </kwd-group>
    </article-meta>
  </front>
  <body>
    <sec>
      <p>Progress in optical coherent tomography (OCT) has recently provided new insights into variety of chorioretinal disorders. The use of EDI (Enhanced Depth Imaging) during OCT examinations and as well as OCT angiography provides a more accurate analysis of the choroid both quantitatively and qualitatively. „Pachychoroid“ (greek pachy- [παχύ]: thick) is defined as an abnormal and sustained increase in choroidal thickness ≥ 300 μm, which is mainly due to dilated choroidal vessels in the Haller’s layer and other structural changes in physiological choroidal architecture. Central serous chorioretinopathy is one of many macular diseases associated with „pachychoroid“. Another diseases that belong to the group of macular pachychoroid disorders are: pachychoroid pigment epitelopathy, pachychoroid neovasculopathy, polypoid choroidal vasculopathy. In this paper we summarize the current view on pachychoroid macular diseases and describe characteristics that are observed in multimodal imaging analysis of choroidal changes.</p>
    </sec>
  </body>
  <back>
    <ref-list>
      <title>References</title>
      <ref id="R7716">
        <mixed-citation>Alam, S., Zawadzki, RJ., Choi, S. et al.: Clinical application of rapid serial fourier-domain optical coherence tomography for macular imaging. Ophthalmology, 113(8); 2006: 1425–31.</mixed-citation>
      </ref>
      <ref id="R7717">
        <mixed-citation>Aoyagi, R., Hayashi, T., Masai, A. et al.: Subfoveal choroidal thickness in multiple evanescent white dot syndrome. Clin Exp Optom, 95(2); 2012: 212–7.</mixed-citation>
      </ref>
      <ref id="R7718">
        <mixed-citation>Arora, S., Pyare, R., Sridharan, P. et al.: Choroidal thickness evaluation of healthy eyes, central serous chorioretinopathy, and fellow eyes using spectral domain optical coherence tomography in Indian population. Indian J Ophthalmol, 64(10); 2016: 747–751.</mixed-citation>
      </ref>
      <ref id="R7719">
        <mixed-citation>Azar, G., Wolff, B., Mauget-Faÿsse, M. et al.: Pachychoroid neovasculopathy: aspect on optical coherence tomography angiography. Acta Ophthalmol, 95(4); 2017: 421-427.</mixed-citation>
      </ref>
      <ref id="R7720">
        <mixed-citation>Bonini Filho, MA., de Carlo, TE., Ferrara, D. et al.: Association of Choroidal Neovascularization and Central Serous Chorioretinopathy with Optical Coherence Tomography Angiography. JAMA Ophthalmol, 133; 2015: 899–906.</mixed-citation>
      </ref>
      <ref id="R7721">
        <mixed-citation>Dansingani, KK., Balaratnasingam, C., Naysan, J. et al.: En face imaging of pachychoroid spectrum disorders with swept-source optical coherence tomography. Retina, 36(3); 2016: 499–516.</mixed-citation>
      </ref>
      <ref id="R7722">
        <mixed-citation>de Jong, EK., Breukink, MB., Schellevis, RL. et al.: Chronic central serous chorioretinopathy is associated with genetic variants implicated in age-related macular degeneration. Ophthalmology, 44(4); 2003: 1696–703.</mixed-citation>
      </ref>
      <ref id="R7723">
        <mixed-citation>Drexler, W., Morgner, U., Ghanta, RK. et al.: Ultrahigh-resolution ophthalmic optical coherence tomography. Nat Med, 7(5); 2001: 636.</mixed-citation>
      </ref>
      <ref id="R7724">
        <mixed-citation>Ersoz, MG., Karacorlu, M., Arf, S. et al.: Outer nuclear layer in pachychoroid pigment epitheliopathy. Retina, 2017: [Epub ahead of print]</mixed-citation>
      </ref>
      <ref id="R7725">
        <mixed-citation>Ersoz, MG., Karacorlu, M., Arf, S. et al.: Pachychoroid pigment epitheliopathy in fellow eyes of patients with unilateral central serous chorioretinopathy. Br J Ophthalmol, 2017: [Epub ahead of print]</mixed-citation>
      </ref>
      <ref id="R7726">
        <mixed-citation>Freund, KB., Pang, CE.: Pachychoroid Neovasculopathy. Retina, 35; 2015: 1–9.</mixed-citation>
      </ref>
      <ref id="R7727">
        <mixed-citation>Fung, AT., Yannuzzi, LA., Freund, KB.: Type 1 (sub-retinal pigment epithelial) neovascularization in central serous chorioretinopathy masquerading as neovascular age-related macular degeneration. Retina, 32(9); 2012: 1829–37.</mixed-citation>
      </ref>
      <ref id="R7728">
        <mixed-citation>Gass, JDM.: Pathogenesis of disciform detachment of the neuroepithelium. II. Idiopathic central serous choroidopathy. Am J Ophthalmol, 63; 1967: 587– 615.</mixed-citation>
      </ref>
      <ref id="R7729">
        <mixed-citation>Gemenetzi, M., De Salvo, G., Lotery, AJ.: Central serous chorioretinopathy: an update on pathogenesis and treatment. Eye, 24; 2010: 1743–1756.</mixed-citation>
      </ref>
      <ref id="R7730">
        <mixed-citation>Gloesmann, M., Hermann, B., Schubert, C. et al.: Histologic correlation of pig retina radial stratification with ultrahigh-resolution optical coherence tomography. Invest Ophthalmol Vis Sci,</mixed-citation>
      </ref>
      <ref id="R7731">
        <mixed-citation>Goldenberg, D., Moisseiev, E., Goldstein, M. et al.: Enhanced depth imaging optical coherence tomography: choroidal thickness and correlations with age, refractive error, and axial len- gth. Ophthalmic Surg Lasers Imaging, 43(4); 2012: 296–301.</mixed-citation>
      </ref>
      <ref id="R7732">
        <mixed-citation>Huang, D., Swanson, EA., Lin, CP. et al.: Optical coherence tomography. Science, 254(5035); 1991: 1178–81.</mixed-citation>
      </ref>
      <ref id="R7733">
        <mixed-citation>Chrapek, O., Řehák, J.: Léčba centrální serózní chorioretinopatie – naše zkušenosti. Čes. a slov. Oftal, 1; 2002: 51-56</mixed-citation>
      </ref>
      <ref id="R7734">
        <mixed-citation>Ie, D., Yannuzi, LA., Spaide, RF. et al.: Subretinal exudative deposits in central serous chorioretinopathy. Br J Ophthalmol, 77; 1993: 349–53.</mixed-citation>
      </ref>
      <ref id="R7735">
        <mixed-citation>Kawamura, A., Yuzawa, M., Mori, R. et al.: Indocyanine green angiographic and optical coherence tomographic findings support classification of polypoidal choroidal vasculopathy into two types. Acta Ophthalmol, 91(6); 2013: e474–e481.</mixed-citation>
      </ref>
      <ref id="R7736">
        <mixed-citation>Lehmann, M., Bousquet, E., Beydoun, T.: Pachychoroid: an inherited condition? Retina, 35(1); 2015: 10-6.</mixed-citation>
      </ref>
      <ref id="R7737">
        <mixed-citation>Lin, WY., Yang, SC., Chen, SJ. et al.: Automatic segmentation of polypoidal choroidal vasculopathy from indocyanine green angiography using spatial and temporal patterns. Transl Vis Sci Technol, 4(2); 2015: 7</mixed-citation>
      </ref>
      <ref id="R7738">
        <mixed-citation>Margolis, R., Spaide, RF.: A pilot study of enhanced depth imaging optical coherence tomography of the choroid in normal eyes. Am J Ophthalmol, serous chorioretinopathy quantified using swept-source optical coherence tomography. Am J Ophthalmol, 169; 2016: 199–207.</mixed-citation>
      </ref>
      <ref id="R7739">
        <mixed-citation>Maruko, I., Iida, T., Sugano, Y. et al.: Subfoveal choroidal thickness after treatment of Vogt-Koyanagi-Harada disease. Retina, 31(3); 2011: 510–7.</mixed-citation>
      </ref>
      <ref id="R7740">
        <mixed-citation>Matsumoto, H., Kishi, S., Otani, T. et al.: Elongation of photoreceptor outer segment in central serous chorioretinopathy. Am J Ophthalmol, 145; 2008: 162–8.</mixed-citation>
      </ref>
      <ref id="R7741">
        <mixed-citation>Matušková, V.: Centrální serózní cho - rioretinopatie jako maskující syndrom choroidálního hemangiomu. Čes. a slov. Oftal, 72(6); 2016: 209-214</mixed-citation>
      </ref>
      <ref id="R7742">
        <mixed-citation>Mrejen, S., Spaide, RF.: Optical coherence tomography: imaging of the choroid and beyond. Surv Ophthalmol, 58(5); 2013: 387–429.</mixed-citation>
      </ref>
      <ref id="R7743">
        <mixed-citation>Ojima, A., Iida, T., Sekiryu, T. et al.: Photopigments in central serous chorioretinopathy. Am J Ophthalmol, 151; 2011: 940–52.</mixed-citation>
      </ref>
      <ref id="R7744">
        <mixed-citation>Ooto, S., Kuroda, Y., Yoshimura, N.: Increased choroidal vascularity in central panuveitis and punctate inner choroidopathy through multimodal imaging. Retina, 33(7); 2013: 1315–24.</mixed-citation>
      </ref>
      <ref id="R7745">
        <mixed-citation>Pang, CE., Freund, KB.: Pachychoroid ne - ovasculopathy. Retina, 35(1); 2015: 1–9.</mixed-citation>
      </ref>
      <ref id="R7746">
        <mixed-citation>Pang, CE., Shah, VP., Sarraf, D. et al.: Ultra-widefield imaging with autofluorescence and indocyanine green angiography in central serous chorioretinopathy. Am J Ophthalmol, 158(2); 2014: 362– 371.e2.</mixed-citation>
      </ref>
      <ref id="R7747">
        <mixed-citation>Rosa, Dolz-Marco., Kunal, K., Dansingani, K.: The pachychoroid clinical spectrum. [online] Retina Today. May/ June 2016. Dostupné na www: &lt;http:// retinatoday.com/2016/06/the-pachychoroid-clinical-spectrum/&gt;.</mixed-citation>
      </ref>
      <ref id="R7748">
        <mixed-citation>Spaide, RF., Campeas, L., Haas, A. et al.: Central serous chorioretinopathy in younger and older adults. Ophthalmology, 103; 1996: 2070–9.</mixed-citation>
      </ref>
      <ref id="R7749">
        <mixed-citation>Spaide, RF., Goldberg, N., Freund, KB.: Redefining multifocal choroiditis and 147(5); 2009: 811–5.</mixed-citation>
      </ref>
      <ref id="R7750">
        <mixed-citation>Spaide, RF., Koizumi, H., Pozzoni, MC.: Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol, 146(4); 2008: 496– 500.</mixed-citation>
      </ref>
      <ref id="R7751">
        <mixed-citation>Von Graefe, A.: Uebercentralerecidivi - erende retinitis. Graefes Arch Clin Exp Ophthalmol, 12; 1866: 211–15.</mixed-citation>
      </ref>
      <ref id="R7752">
        <mixed-citation>Warrow, DJ., Hoang, QV., Freund, KB.: Pachychoroid pigment epitheliopathy. Retina, 33(8); 2013: 1659–1672.</mixed-citation>
      </ref>
      <ref id="R7753">
        <mixed-citation>Yannuzzi, LA., Sorenson, J., Spaide, RF. et al.: Idiopathic polypoidal choroidal vasculopathy (IPCV). Retina, 10(1); 1990: 1-8.</mixed-citation>
      </ref>
      <ref id="R7754">
        <mixed-citation>Yoneyama, S., Sakurada, Y., Kikushima, W. et al.: Genetic factors associated with choroidal vascular hyperpermeability and subfoveal choroidal thickness polypoidal choroidal vasculopathy. Retina, 36(8); 2016: 1535-41.</mixed-citation>
      </ref>
    </ref-list>
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</article>
